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Binding of Thiostrepton to Ribosomes from Thiostrepton-Sensitive and -Resistant Bacillus subtilis Strains

By Robert Vince, David Weiss, Julian Gordon, Guy Howard, Issar Smith and Sidney Pestka


Binding of [(35)S]thiostrepton to ribosomes from thiostrepton-sensitive and -resistant strains of Bacillus subtilis was studied. Ribosomes from thiostrepton-resistant strains bound relatively little thiostrepton compared with ribosomes from thiostrepton-sensitive B. subtilis. In addition, ribosomes from revertant strains that were obtained as thiostrepton-sensitive revertants from thiostrepton-resistant strains bound [(35)S]thiostrepton similarly to ribosomes from the sensitive parental strain

Topics: Chemistry; Mechanisms of Action and Resistance
Year: 1976
DOI identifier: 10.1128/aac.9.4.665
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Provided by: PubMed Central
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