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Concentration of Clindamycin in Human Bone

By Peter Nicholas, Burt R. Meyers, Roger N. Levy and Shalom Z. Hirschman


Thirty patients undergoing total hip replacement received clindamycin beginning the day before surgery. Mean clindamycin concentrations during surgery were 7.33 ± 3.37 μg/ml in serum and 2.63 ± 1.76 μg/g in bone; mean ratio of bone-serum concentration was 0.40 ± 0.30

Topics: Pharmacology and Therapeutics
Year: 1975
DOI identifier: 10.1128/aac.8.2.220
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Provided by: PubMed Central
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