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The Amplification of Ribosomal RNA Genes Involves a Rolling Circle Intermediate

By Dennis Hourcade, David Dressler and John Wolfson

Abstract

During the development of Xenopus oocytes there is a special DNA synthesis that leads to a thousandfold amplification of the genes that code for ribosomal RNA. We have used the electron microscope to study this process. Our primary observation is the presence of ribosomal DNA in rolling-circle intermediates at the time of amplification. We believe that these intermediates are involved in the amplification process, and as such offer the first example of the involvement of a rolling circle in the replication of eukaryotic DNA

Topics: Biological Sciences: Cell Biology
Year: 1973
DOI identifier: 10.1073/pnas.70.10.2926
OAI identifier: oai:pubmedcentral.nih.gov:427140
Provided by: PubMed Central
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