Article thumbnail
Location of Repository

The Amplification of Ribosomal RNA Genes Involves a Rolling Circle Intermediate

By Dennis Hourcade, David Dressler and John Wolfson


During the development of Xenopus oocytes there is a special DNA synthesis that leads to a thousandfold amplification of the genes that code for ribosomal RNA. We have used the electron microscope to study this process. Our primary observation is the presence of ribosomal DNA in rolling-circle intermediates at the time of amplification. We believe that these intermediates are involved in the amplification process, and as such offer the first example of the involvement of a rolling circle in the replication of eukaryotic DNA

Topics: Biological Sciences: Cell Biology
Year: 1973
DOI identifier: 10.1073/pnas.70.10.2926
OAI identifier:
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.