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Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.

By S Weber, J E Zuckerman, D G Bostwick, K G Bensch, B I Sikic and T A Raffin

Abstract

Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC

Topics: Research Article
Year: 1985
DOI identifier: 10.1172/jci111690
OAI identifier: oai:pubmedcentral.nih.gov:423441
Provided by: PubMed Central
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