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Polyarthritis Associated with Salmonella Infection in Rats

By Alvin Volkman and Frank M. Collins


Rats infected intravenously with Salmonella enteritidis develop a chronic destructive polyarthritis. The joint lesions resemble those of human rheumatoid arthritis in distribution and pathology. On the basis of histological and microbiological studies, involvement does not appear to be the result of intra-articular sepsis. Instead, the data favor the view that transient infection incites an immunological response that localizes in the joint and becomes destructive

Topics: Bacterial and Mycotic Infections
Year: 1973
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Provided by: PubMed Central
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