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Role of Delayed Hypersensitivity in Blastomycosis of Mice

By Harry D. Spencer and George C. Cozad


C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 × 10(4) viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells

Topics: Bacterial and Mycotic Infections
Year: 1973
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Provided by: PubMed Central
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