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Comparative Studies of Plaque Variants Derived From a Florida Strain of Venezuelan Equine Encephalomyelitis Virus

By Carl E. Pedersen, Donald R. Slocum and David M. Robinson


Small- and large-plaque variants of a Florida strain (Fe 3-7c) of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed

Topics: Viral Infections
Year: 1972
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Provided by: PubMed Central
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