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Inhibit GSK-3β or there’s heartbreak dead ahead

By Elizabeth Murphy

Abstract

Numerous signaling pathways have been shown to mediate cardioprotection, but the end effectors that mediate protection are only beginning to be elucidated. Numerous cardioprotective drugs are shown to converge on glycogen synthase kinase-3β (GSK-3β) . The phosphorylation and inhibition of GSK-3β lead to inhibition or delayed activation of the mitochondrial permeability transition, a key regulator of apoptosis

Topics: Commentary
Publisher: American Society for Clinical Investigation
Year: 2004
DOI identifier: 10.1172/JCI200421986
OAI identifier: oai:pubmedcentral.nih.gov:419495
Provided by: PubMed Central
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