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Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum.

By J L McDonel and C L Duncan


Highly purified enterotoxin from Clostridium perfringens was found to have histopathological activity in the rabbit ileum. Unlike the action of cholera, Escherichia coli, and Shigella enterotoxins, epithelium was denuded from the tips of ileal villi at concentrations of the enterotoxin necessary to induce fluid accumulation in the rabbit. Whether or not this observed histopathology is essential for the diarrheal syndrome associated with Clostridium perfringens food poisoning remains unclear

Topics: Research Article
Year: 1975
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Provided by: PubMed Central
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