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Synthesis and biological activity of human inhibin-like peptide-(1-31).

By D Yamashiro, C H Li, K Ramasharma and M R Sairam


A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the synthetic peptide was comparable to that of the natural product. It was also active in suppressing lutropin-releasing hormone-induced follitropin release in vivo in immature male rats

Topics: Research Article
Year: 1984
DOI identifier: 10.1073/pnas.81.17.5399
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Provided by: PubMed Central
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