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Assignment of the gene for human DNA polymerase alpha to the X chromosome.

By T S Wang, B E Pearson, H A Suomalainen, T Mohandas, L J Shapiro, J Schröder and D Korn


We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase alpha in rodent-human somatic cell hybrid clones to identify a single genetic locus that is both necessary and sufficient for the expression of DNA polymerase alpha. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome

Topics: Research Article
Year: 1985
DOI identifier: 10.1073/pnas.82.16.5270
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Provided by: PubMed Central
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