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Polyurethane/Tricalcium Phosphate Bone Adhesives and Substitutes for Load Bearing Applications

By Semih Sahan, Pezhman Hosseinian, Deniz Ozdil, Mustafa Turk and Halil Murat Aydin

Abstract

WOS: 000398929400009The large mechanical forces throughout the sternum and upon the tibia, impact healing capacities following sternotomies and upper tibia osteotomies, respectively. In these fields, there remains a need for materials with a strong adhesive capacity, high mechanical strength when set(1,2) and sufficient porosity to allow osteointegration. The present work investigates castor oil-based polyurethanes synthesized and combined with beta-tricalcium phosphate (beta-TCP) granules for use as bone graft substitutes or adhesives in load-bearing regions. The material is produced via a reaction involving castor oil, caprolactone monomers, an aliphatic diamine-based catalyst and water, with the CO2 gas product creating pores throughout the structure. beta-TCP particles 1000-2000 mu m in diameter that were added to the mixture compose the ceramic phase of the material. Setting completely after 24 hours, the adhesive cubic bone grafts exhibited a 97% structural porosity, Young's Modulus of around 44 MPa, biocompatibility, cell attachment and tissue ingrowth and no apoptotic or necrotic effects. With a fully interconnected porous structure and adhesive qualities, this adhesive bone graft material holds potential for the reconstruction of challenging regions such as the sternum, upper tibia and mandible. Furthermore, the bone grafts can be offered as pre-formed, off-the-shelf products.TUBITAK-TEYDEB Programme [7131048]; BMT Calsis Co.The authors would like to acknowledge and thank the TUBITAK-TEYDEB Programme (Grant No: 7131048) and BMT Calsis Co. for providing financial support to this work

Topics: Polyurethanes, Tricalcium Phosphate, Bone Regeneration, Load Bearing, Bone Adhesives
Publisher: 'American Scientific Publishers'
Year: 2017
DOI identifier: 10.1166/jbt.2017.1585
OAI identifier: oai:acikerisim.kku.edu.tr:20.500.12587/6993
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