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Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein*

By Jean-Pierre Changeux, Michiki Kasai and Chen-Yuan Lee

Abstract

α-Bungarotoxin, a polypeptide of mol wt 8000 purified from the venom of Bungarus multicinctus, blocks irreversibly and specifically the excitation by cholinergic agonists on the isolated electroplax and on purified membrane fragments in vitro. The toxin also blocks the in vitro binding of decamethonium to a protein recently isolated from electric tissue. This observation strengthens our earlier conclusion that this protein is the cholinergic receptor macromolecule

Topics: Biological Sciences: Biochemistry
Year: 1970
OAI identifier: oai:pubmedcentral.nih.gov:283343
Provided by: PubMed Central
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