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Identification of Proinsulin and C-Peptide in Human Serum by a Specific Immunoassay*

By Franco Melani, Arthur H. Rubenstein, Philip E. Oyer and Donald F. Steiner


An immunoassay for the measurement of human proinsulin and C-peptide is described. By a combination of this system and an insulin immunoassay, proinsulin, insulin, and C-peptide were identified in acid-ethanol extracts of serum after gel filtration. In keeping with the results of biosynthetic studies, insulin and C-peptide were found to be present in equimolar amounts. The absolute values of serum proinsulin determined independently in the two assays corresponded closely

Topics: Biological Sciences: Medical Sciences
Year: 1970
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Provided by: PubMed Central
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