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Interleukin-7 enhances antimicrobial activity against Leishmania major in murine macrophages.

By A Gessner, M Vieth, A Will, K Schröppel and M Röllinghoff

Abstract

Recently, it has been shown that interleukin-7 (IL-7) is able to induce secretion of cytokines and tumoricidal activity by human monocytes. This study shows that treatment of murine macrophages infected with Leishmania major with IL-7 without any other stimulus reduced the percentage of infected cells, as well as the parasite burden per cell, in a dose-dependent manner to a limited degree (45% reduction of the number of amastigotes per 100 macrophages). Simultaneous treatment of macrophages with gamma interferon and IL-7 led to nearly complete (> 99%) elimination of amastigotes. Addition of anti-tumor necrosis factor alpha or N omega-monomethyl-L-arginine acetate reversed the leishmanicidal effects of IL-7, and production of nitric oxide was induced in the presence of IL-7

Topics: Research Article
Year: 1993
OAI identifier: oai:pubmedcentral.nih.gov:281110
Provided by: PubMed Central
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