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Thymineless Death in Escherichia coli: Strain Specificity

By Donald J. Cummings and Lee Mondale

Abstract

Thymineless death of various ultraviolet (UV)-sensitive strains of Escherichia coli B and K-12 was investigated. It was found that E. coli B, Bs−12, K-12 rec-21, and possibly K-12 Lon−, all sensitive to UV, were also sensitive to thymine starvation. However, other UV-sensitive strains of E. coli were found to display the typical resistant-type kinetics of thymineless death. The correlation of these results with various other cellular processes suggested that the filament-forming ability of the bacteria might be involved in the mechanism of thymineless death. It was apparent from the present results that capacity for host-cell reactivation, recombination ability, thymine dimer excision, and probably induction of a defective prophage had little to do with determining sensitivity to thymine deprivation

Topics: Genetics and Molecular Biology
Year: 1967
OAI identifier: oai:pubmedcentral.nih.gov:276711
Provided by: PubMed Central
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