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LRP: a bright beacon at the blood-brain barrier

By Joachim Herz

Abstract

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection. By interacting with active tissue-type plasminogen activator, LDL receptor–related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family

Topics: Commentary
Publisher: American Society for Clinical Investigation
Year: 2003
DOI identifier: 10.1172/JCI200320337
OAI identifier: oai:pubmedcentral.nih.gov:259136
Provided by: PubMed Central
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