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Properties of the B oligomer of pertussis toxin.

By L Nencioni, M G Pizza, G Volpini, M T De Magistris, F Giovannoni and R Rappuoli

Abstract

The B oligomer of pertussis toxin was purified from culture supernatants of Bordetella pertussis strains which do not secrete the S1 subunit. The purified B oligomer is devoid of toxicity for CHO cells and other in vivo properties of the toxin, such as leukocytosis and histamine sensitization, but it retains the abilities to agglutinate erythrocytes and to induce the proliferation of T lymphocytes. The B oligomer is also able to induce protective immunity in mice but is less potent than molecules containing the S1 subunit also

Topics: Research Article
Year: 1991
OAI identifier: oai:pubmedcentral.nih.gov:259109
Provided by: PubMed Central
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