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Murine resistance to street rabies virus: genetic analysis by testing second-backcross progeny and verification of allelic resistance genes in SJL/J and CBA/J mice.

By D L Lodmell and B Chesebro

Abstract

Intraperitoneal challenge with street rabies virus of second-backcross offspring produced from susceptible females mated with either randomly selected or rabies-resistant first-backcross males indicated that murine resistance is under the influence of the concurrent presence of each of two segregating genes. Furthermore, the greater than or equal to 96% resistance of offspring produced from (SJL X CBA)F1 and (CBA X SJL)F1 hybrids crossed to susceptible A.SW or A/WySn mice demonstrated that resistance genes of SJL/J and CBA/J mice are allelic

Topics: Research Article
Year: 1984
OAI identifier: oai:pubmedcentral.nih.gov:255628
Provided by: PubMed Central
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