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A determinant of polyomavirus virulence enhances virus growth in cells of renal origin.

By J B Bolen, S E Fisher, K Chowdhury, T C Shan, J E Williams, C J Dawe and M A Israel


We have identified a strain of polyomavirus, Py(L), which is unusual in causing acute morbidity and early death after inoculation of newborn mice. We determined that these animals died of kidney failure associated with extensive, virus-mediated destruction of renal tissue. Interestingly, the Py(L) strain infects baby mouse kidney cell cultures more efficiently than do other strains

Topics: Research Article
Year: 1985
OAI identifier: oai:pubmedcentral.nih.gov:255049
Provided by: PubMed Central
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