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Analysis of Ribosomes from Viomycin-Sensitive and -Resistant Strains of Mycobacterium smegmatis

By Takeshi Yamada, Kunitsugu Masuda, Ko Shoji and Mitsuo Hori


Viomycin-resistant strains were isolated from Mycobacterium smegmatis. Ribosomes were isolated and tested for drug resistance in subcellular systems containing poly(U) as messenger ribonucleic acid. Resistance to viomycin in these strains was due to altered ribosomes. Further analysis showed that viomycin resistance of two mutants with low level resistance (20 μg/ml) was due to altered 30S ribosomal subunits. Another mutant that was highly resistant to viomycin (1 mg/ml), however, had altered 50S ribosomal subunits

Topics: Genetics and Molecular Biology
Year: 1972
OAI identifier: oai:pubmedcentral.nih.gov:251373
Provided by: PubMed Central
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