Article thumbnail

Identification and consequences of miRNA-target interactions - beyond repression of gene expression

By Jean Hausser and Mihaela Zavolan


Comparative genomics analyses and high-throughput experimental studies indicate that a microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the knockout of components of the miRNA biogenesis pathway has profound phenotypic consequences, most predicted miRNA targets undergo small changes at the mRNA and protein levels when the expression of the miRNA is perturbed. Alternatively, miRNAs can establish thresholds in and increase the coherence of the expression of their target genes, as well as reduce the cell-to-cell variability in target gene expression. Here, we review the recent progress in identifying miRNA targets and the emerging paradigms of how miRNAs shape the dynamics of target gene expression

Publisher: Nature Publishing Group
Year: 2014
DOI identifier: 10.1038/nrg3765
OAI identifier:
Provided by: edoc
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles