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Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome.

By A Ramsingh, A Hixson, B Duceman and J Slack

Abstract

A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant

Topics: Research Article
Year: 1990
OAI identifier: oai:pubmedcentral.nih.gov:249496
Provided by: PubMed Central
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