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Mechanism of Inactivation of Transforming Deoxyribonucleic Acid by X Rays

By M. L. Randolph and Jane K. Setlow


Transforming deoxyribonucleic acid (DNA) from Haemophilus influenzae was exposed to X rays either in phosphate buffer or in 10% yeast extract. Relations between determinations of biological inactivation, DNA uptake by competent H. influenzae, integration of DNA into the competent cell genome, and induced single-and double-strand breaks indicate that transforming DNA is inactivated by the direct and the indirect effect of X radiation primarily because integration of DNA is prevented as a result of the production of double-strand breaks

Topics: Genetics and Molecular Biology
Year: 1971
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Provided by: PubMed Central
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