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Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes.

By W C Brown, L Bissey, K S Logan, N C Pedersen, J H Elder and E W Collisson

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo

Topics: Research Article
Year: 1991
OAI identifier: oai:pubmedcentral.nih.gov:240997
Provided by: PubMed Central
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