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Microbial transformation of primaquine by Candida tropicalis.

By A M Clark, C D Hufford, R C Gupta, R K Puri and J D McChesney

Abstract

The microbial metabolism of primaquine, a 6-methoxy-8-aminoquinoline antimalarial agent, was investigated. The yeast Candida tropicalis was found to convert primaquine to the previously reported N-acetylated derivative. On continued incubation of C. tropicalis in the presence of the N-acetylated derivative, a minor dimeric metabolite was formed. The proposed structure of the metabolite was based primarily on the analysis of its spectroscopic properties (1H and 13C nuclear magnetic resonance spectra and field-desorption mass spectrum). The structure of the metabolite was proven by direct comparison with an authentic sample of the minor dimeric metabolite prepared by treatment of the N-acetylated derivative with formaldehyde in the presence of formic acid in methanol

Topics: Research Article
Year: 1984
OAI identifier: oai:pubmedcentral.nih.gov:239716
Provided by: PubMed Central
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