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Cell culture adaptation of astrovirus involves a deletion.

By M M Willcocks, N Ashton, J B Kurtz, W D Cubitt and M J Carter

Abstract

Astroviruses have been adapted to culture by serial blind passage in primary human embryo cells. All viruses thus adapted possess a 45-nucleotide deletion relative to fecal viruses or isolates made in CaCo-2 cells; this deletion may be responsible for the change in host cell range

Topics: Research Article
Year: 1994
OAI identifier: oai:pubmedcentral.nih.gov:237012
Provided by: PubMed Central
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