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Decreased elastin in vessel walls puts the pressure on

By Jeanine D’Armiento


Mice haploinsufficient for elastin develop structural changes in vessel walls similar to those seen in patients with mutations in the elastin gene. A new study demonstrates that due to mechanical changes in the vessel wall, these animals exhibit increased mean arterial pressures. The results evoke the possibility that alterations in elastin may contribute to the development of essential hypertension in patients

Topics: Commentary
Publisher: American Society for Clinical Investigation
Year: 2003
DOI identifier: 10.1172/JCI200320226
OAI identifier:
Provided by: PubMed Central
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