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Oral Vaccination of Mice with Adenoviral Vectors Is Not Impaired by Preexisting Immunity to the Vaccine Carrier

By Z. Q. Xiang, G. P. Gao, A. Reyes-Sandoval, Y. Li, J. M. Wilson and H. C. J. Ertl

Abstract

E1 deletion adenoviral vectors of the human serotype 5 (AdHu5) and the chimpanzee serotype 68 (AdC68) expressing the rabies virus glycoprotein (rab.gp) were tested for induction of transgene product-specific antibodies upon intranasal or oral immunization of newborn mice. Both vectors induced antibodies to rabies virus that could be detected in serum and mucosal secretions. Serum rabies virus-neutralizing antibody titers sufficed to protect neonatally vaccinated mice against a subsequent challenge with rabies virus. The efficacy of the AdHu5rab.gp vector given orally to newborn mice born to AdHu5-immune dams was not impaired by maternally transferred antibodies to the vaccine carrier

Topics: Vaccines and Antiviral Agents
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/JVI.77.20.10780-10789.2003
OAI identifier: oai:pubmedcentral.nih.gov:224991
Provided by: PubMed Central
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