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INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK*

By Jose M. Musacchio, Louis Julou, Seymour S. Kety and Jacques Glowinski

Abstract

A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals

Topics: Biological Sciences: Physiology
Year: 1969
OAI identifier: oai:pubmedcentral.nih.gov:223437
Provided by: PubMed Central
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