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STUDIES OF THE AROMATIC CIRCULAR DICHROISM OF STAPHYLOCOCCAL NUCLEASE

By Gilbert S. Omenn, Pedro Cuatrecasas and Christian B. Anfinsen

Abstract

Specific contributions of tyrosyl and of tryptophanyl residues can be distinguished in the near-ultraviolet circular dichroic spectrum of staphylococcal nuclease. Upon binding of the inhibitor deoxythymidine 3′,5′-diphosphate in the presence of Ca++, a significant change in the circular dichroic spectrum results which has been used to characterize the interaction of ligand and enzyme. The data suggest that the asymmetric environment of certain tyrosyl residues is altered by binding of the nucleotide inhibitor

Topics: Biological Sciences: Biochemistry
Year: 1969
OAI identifier: oai:pubmedcentral.nih.gov:223323
Provided by: PubMed Central
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