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Preferential inhibition of plasmid replication in vivo by altered DNA gyrase activity in Escherichia coli.

By B E Uhlin and K Nordström

Abstract

The thermosensitive growth phenotype exerted by runaway-mutant plasmids was suppressed by sublethal doses of the DNA gyrase inhibitors novobiocin or nalidixic acid, although the latter drug was less efficient. A novobiocin-resistant gyrB mutant Escherichia coli strain prevented expression of the runaway phenotype at 37 to 42 degrees C in the absence of any drug

Topics: Research Article
Year: 1985
OAI identifier: oai:pubmedcentral.nih.gov:218936
Provided by: PubMed Central
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