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Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola

By Takayuki Horiuchi, Edward Giniger and Toshiro Aigaki


longitudinals lacking (lola) is a complex Drosophila gene encoding at least 20 protein isoforms,each bearing the same N-terminal constant region linked to a different C-terminal variable region. Different isoforms specify different aspects of axon growth and guidance. We show here that lola mRNAs are generated by alternative trans-splicing of exons sequentially encoded by the same DNA strand. Chromosomal pairing facilitates interallelic trans-splicing,allowing complementation between mutations in the constant and those in the variable exons. We demonstrate that at least one variable exon is transcribed from its own promoter,and trans-spliced to the constant exons transcribed separately

Topics: Research Communications
Publisher: Cold Spring Harbor Laboratory Press
Year: 2003
DOI identifier: 10.1101/gad.1137303
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Provided by: PubMed Central
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