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Changes in serum proteins and immune response\ud in oreochromis mossambicus induced by aflatoxin B

By Sherly Zacharia, P C Thomas and M P Paulton


Studies were conducted to evaluate the molecular changes induced by aflatoxin,\ud the most frequently encountered dietary carcinogen in Oreochromis\ud mossambicus. Three sub-lethal test doses of aflatoxin B1 incorporated in feed\ud (1.5, 5.0 and 15.0mg/kg feed) were given to the fishes for a period of 30 days and\ud the changes in serum protein profile were resolved through SDS PAGE at regular\ud intervals. Similarly, the changes in immune responses were also studied. The\ud study revealed significant changes in both protein profile and immune response\ud in the experimental fishes compared to the control, indicating that the toxin\ud exerts its effect even at sublethal levels

Topics: Fish and Fisheries
Publisher: CMFRI/ICAR
Year: 2003
OAI identifier:

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