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Transcriptional regulation of the proC gene of Salmonella typhimurium.

By R A Brady and L N Csonka


We found that the expression of beta-galactosidase in Salmonella typhimurium strains carrying proC-lacZ fusions was neither repressed by excess proline nor derepressed by proline limitation. Except for a three- to fourfold decrease in the beta-galactosidase specific activity under conditions causing a severely reduced growth rate, the expression of the proC-lacZ fusions was nearly invariant under a variety of culture conditions. Thus, the proC gene is unlike most other amino acid biosynthetic genes in that its expression is nearly constitutive

Topics: Research Article
Year: 1988
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Provided by: PubMed Central
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