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Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.

By P. R. August, M. C. Flickinger and D. H. Sherman

Abstract

Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases

Topics: Research Article
Publisher: American Society for Microbiology (ASM)
Year: 1994
OAI identifier: oai:pubmedcentral.nih.gov:205660
Provided by: PubMed Central
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