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Averufanin is an aflatoxin B1 precursor between averantin and averufin in the biosynthetic pathway.

By S P McCormick, D Bhatnagar and L S Lee

Abstract

Wild-type Aspergillus parasiticus produces, in addition to the colorless aflatoxins, a number of pigmented secondary metabolites. Examination of these pigments demonstrated that a major component was an anthraquinone, averufanin. Radiolabeling studies with [14C]averufanin showed that 23% of the label was incorporated into aflatoxin B1 by the wild type and that 31% of the label was incorporated into O-methylsterigmatocystin by a non-aflatoxin-producing isolate. In similar studies with blocked mutants of A. parasiticus the 14C label from averufanin was accumulated in averufin (72%) and versicolorin A (54%) but not averantin. The results demonstrate that averufanin is a biosynthetic precursor of aflatoxin B1 between averantin and averufin

Topics: Research Article
Year: 1987
OAI identifier: oai:pubmedcentral.nih.gov:203593
Provided by: PubMed Central
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