Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.

Abstract

Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry

Sorry, our data provider has not provided any external links therefor we are unable to provide a PDF.