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THoR: a tool for domain discovery and curation of multiple alignments

By Nicholas J Dickens and Chris P Ponting

Abstract

We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases

Topics: Software
Publisher: BioMed Central
Year: 2003
OAI identifier: oai:pubmedcentral.nih.gov:193644
Provided by: PubMed Central

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