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Biosafety of a 3D printed intraocular lens made of a poly(acrylamide co sodium acrylate) hydrogel in vitro and in vivo

By Jiawen Li, Yijian Li, Xisu Hu, Gong Yu, Bin Xu, Haiwei Xu and Zheng Qin Yin

Abstract

The biosafety of the poly(acrylamide-co-sodium acrylate) hydrogel was first 19 analyzed in vitro using human lens epithelial cells (LECs) and the ARPE19 cell line, and a CCK-8 assay was performed to investigate alterations in cell proliferation. A thin film of a poly(acrylamide-co-sodium acrylate) hydrogel and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively, and a sham surgery served as control group. The anterior segment photographs, intraocular pressure (IOP), blood parameters and electroretinograms were recorded. Inflammatory cytokines in the aqueous humor, such as TNF and IL-8, were examined by ELISA. Cell apoptosis of the retina was investigated by TUNEL assay, and macrophage activation was detected by immunostaining

Topics: B500
Publisher: 'Press of International Journal of Ophthalmology (IJO Press)'
OAI identifier: oai:nrl.northumbria.ac.uk:44021
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