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Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I.

By M Fukasawa, Y Sumita, E T Harabe, T Tanio, H Nouda, T Kohzuki, T Okuda, H Matsumura and M Sunagawa

Abstract

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1 beta-methyl substituent on carbapenems, i.e., meropenem and 1 beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are

Topics: Research Article
Year: 1992
DOI identifier: 10.1128/aac.36.7.1577
OAI identifier: oai:pubmedcentral.nih.gov:191626
Provided by: PubMed Central
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