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Herpes simplex virus type 2 inhibition of Fas ligand expression.

By S Sieg, Z Yildirim, D Smith, N Kayagaki, H Yagita, Y Huang and D Kaplan


Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common human pathogens. In this report we demonstrate the capacity of HSV-2, but not HSV-1, to inhibit the activity and cell surface expression of Fas ligand, an important molecule involved in T-cell apoptosis and cell-mediated cytotoxicity. Cells infected with HSV-2 retained Fas ligand intracellularly instead of expressing it on the cell surface. Addition of anti-Fas antibodies markedly inhibited HSV-2 viral production, suggesting that the capacity of the virus to regulate Fas ligand expression, and thereby programmed cell death, may represent a powerful mechanism for the virus to enhance viral replication

Topics: Research Article
Year: 1996
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Provided by: PubMed Central
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