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Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization.

By P Gómez-Puertas, F Rodríguez, J M Oviedo, F Ramiro-Ibáñez, F Ruiz-Gonzalvo, C Alonso and J M Escribano


African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization

Topics: Research Article
Year: 1996
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Provided by: PubMed Central
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