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The Epstein-Barr virus 3.5-kilobase latent membrane protein 1 mRNA initiates from a TATA-Less promoter within the first terminal repeat.

By R H Sadler and N Raab-Traub

Abstract

The complete 5' sequence of the Epstein-Barr virus 3.5-kb latent membrane protein 1 (LMP1) mRNA, expressed in nasopharyngeal carcinoma, has been determined. The transcript initiates from heterogeneous start sites within the first terminal repeat (TR) of the viral genome. This region is TATA-less, consistent with heterogeneous starting, but contains multiple GC-rich elements which potentially interact with the Sp1 transcription factor. Expression of the 3.5-kb mRNA was consistently detected in nasopharyngeal carcinoma samples and in additional cell types, including a Burkitt's lymphoma. This is the first identification of an Epstein-Barr virus mRNA containing TR sequence and the first report of the ability of the TR to function as a transcriptional promoter

Topics: Research Article
Year: 1995
OAI identifier: oai:pubmedcentral.nih.gov:189209
Provided by: PubMed Central
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