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Intracellular Survival of Streptococcus pyogenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence

By Eva Medina, Manfred Rohde and Gursharan S. Chhatwal

Abstract

It has recently been shown that survival within phagocytic cells constitutes an additional strategy used by Streptococcus pyogenes to evade the host defenses. Here we provide evidence that S. pyogenes can escape from the phagosome into the cytoplasm of phagocytic cells. Furthermore, intracellular bacteria seem to undergo phenotypic switching that results in much more virulent microorganisms

Topics: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/IAI.71.9.5376-5380.2003
OAI identifier: oai:pubmedcentral.nih.gov:187312
Provided by: PubMed Central
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