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Emodin, a Toxic Metabolite of Aspergillus wentii Isolated from Weevil-Damaged Chestnuts

By John M. Wells, Richard J. Cole and Jerry W. Kirksey

Abstract

A diarrheagenic toxin from culture extracts of Aspergillus wentii Wehmer isolated from weevil-damaged Chinese chestnuts was identified as emodin (2-methyl-4,5,7-trihydroxyanthraquinone). The orange-red, crystalline toxin (mp 255 to 257 C) showed ultraviolet absorption maxima in ethyl alcohol at 223, 250, 267, 290, and 442 nm, and infrared absorption maxima at 3,400 cm(-1) (OH), 1,635, and 1,625 cm(-1). Chemical shifts and coupling constants of the proton magnetic resonance spectra of the A. wentii toxin and of authentic emodin agreed. Mean lethal dose of emodin orally administered to 1 day old DeKalb cockerels was 3.7 mg/kg

Topics: Mycotoxins
Year: 1975
OAI identifier: oai:pubmedcentral.nih.gov:187107
Provided by: PubMed Central
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