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Minimal Introns Are Not “Junk”

By Jun Yu, Zhiyong Yang, Miho Kibukawa, Marcia Paddock, Douglas A. Passey and Gane Ka-Shu Wong


Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their “minimal intron” size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus

Topics: Letter
Publisher: Cold Spring Harbor Laboratory Press
Year: 2002
DOI identifier: 10.1101/gr.224602
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Provided by: PubMed Central
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