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The role of a Williams-Beuren syndrome-associated helix–loop–helix domain-containing transcription factor in activin/nodal signaling

By Colleen Ring, Souichi Ogata, Lauren Meek, Jihwan Song, Tatsuru Ohta, Kohei Miyazono and Ken W.Y. Cho

Abstract

We investigated the regulation of the activin/nodal-inducible distal element (DE) of the Xenopus goosecoid (gsc) promoter. On the basis of its interaction with the DE, we isolated a Xenopus homolog of the human Williams-Beuren syndrome critical region 11 (XWBSCR11), and further, show that it interacts with pathway-specific Smad2 and Smad3 in a ligand-dependent manner. Interestingly, we also find that XWBSCR11 functions cooperatively with FoxH1 (Fast-1) to stimulate DE-dependent transcription. We propose a mechanism in which FoxH1 functions together with Smads as a cofactor for the recruitment of transcription factors like XWBSCR11 in the process of activin/nodal-mediated gsc-specific induction. This mechanism provides considerable opportunities for modulation of transcription across a variety of activin/nodal-inducible genes, increasing diversity in promoter selection, thus leading to the differential induction of activin/nodal target genes

Topics: Research Paper
Publisher: Cold Spring Harbor Laboratory Press
Year: 2002
DOI identifier: 10.1101/gad.963802
OAI identifier: oai:pubmedcentral.nih.gov:186325
Provided by: PubMed Central
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