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New Spanish Broom dressings based on Vitamin E and Lactobacillus plantarum for superficial skin wounds

By Beatrice Vitali Barbara Luppi Federica Bigucci Angela Abruzzo Francesco Dalena Carola Parolin Cecilia Prata Luz Maria Melgoza Barbara Giordani Teresa Cerchiara


The focus of this work was to develop innovative dressings based on Spanish Broom gauzes loaded with Vitamin E 12 Lactobacillus plantarum association for the treatment of skin wounds. Vitamin E and L. plantarum, selected for antioxidant and antibacterial properties, were incorporated inside an emulsion containing alginate in the external phase and then lyophilized on Spanish Broom fibers. FT-IR spectroscopy confirmed that Vitamin E was successfully encapsulated inside polymeric coating. The morphology, zeta potential and yield of freeze-dried emulsion were evaluated. Encapsulation efficiency of Vitamin E and L. plantarum was also assessed, as well as release behaviors. Moreover, the Spanish Broom wound dressings were biologically characterized in terms of biocompatibility, antimicrobial and antioxidant activities. Freeze-dried emulsion was able to provide the 100% yield, good entrapment efficiency ( 3c65%) and it guaranteed a good antioxidant activity. Spanish Broom dressing revealed good antimicrobial activities against Staphylococcus aureus and Pseudomonas aeruginosa and it was not toxic to human fibroblasts. Moreover, sustained release of both Vitamin E and L. plantarum were guaranteed over 24 h, as well as a good viability of L. plantarum during storage conditions. In conclusion, Spanish Broom dressing loaded with the freeze-dried emulsion based on Vitamin E 12 L. plantarum could be a promising delivery system for the wound care

Topics: Lactobacillus plantarum, Sodium alginate, Spanish broom fibers, Vitamin E, Wound dressing
Publisher: 'Elsevier BV'
Year: 2020
DOI identifier: 10.1016/j.jddst.2020.101499
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