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Real-Time PCR as a Versatile Tool for Investigating the Susceptibility of Human Herpesvirus 6 to Antiviral Agents

By Muriel Macé, Chaysavanh Manichanh, Pascale Bonnafous, Stéphanie Précigout, David Boutolleau, Agnès Gautheret-Dejean and Henri Agut

Abstract

A quantitative real-time PCR assay was developed for the determination of antiviral drug susceptibility and growth kinetics of human herpesvirus 6. The susceptibility and fitness of a sensitive strain, HST, and its ganciclovir-resistant derivative, GCVR1, were then characterized, leading us to conclude that the mutations of this latter virus did not alter its fitness significantly

Topics: Antiviral Agents
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/AAC.47.9.3021-3024.2003
OAI identifier: oai:pubmedcentral.nih.gov:182648
Provided by: PubMed Central
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